{"id":1517,"date":"2021-10-23T08:15:27","date_gmt":"2021-10-23T08:15:27","guid":{"rendered":"https:\/\/nynkedekkerlab.tudelft.nl\/?p=1517"},"modified":"2021-10-26T06:41:00","modified_gmt":"2021-10-26T06:41:00","slug":"our-manuscript-on-copy-back-synthesis-and-recombination-in-ev-a71-virus-published-in-molecular-cell","status":"publish","type":"post","link":"https:\/\/nynkedekkerlab.tudelft.nl\/?p=1517","title":{"rendered":"Our manuscript on copy-back synthesis and recombination in EV-A71 virus published in Molecular Cell"},"content":{"rendered":"\n<p>We are delighted that our manuscript on copy-back synthesis and recombination in EV-A71 virus is now published in Molecular Cell! Congrats in particular to Richard, Louis, and Bel\u00e9n from our group, as well as to Andrew Woodman of the Craig Cameron group. Thank you to all our other collaborators as well, in particular Shin-Ru Shih, Marco Vignuzzi, and Craig Cameron. The press release can be found <a href=\"https:\/\/www.tudelft.nl\/en\/2021\/tnw\/mechanism-underlying-the-emergence-of-virus-variants-unravelled\">here<\/a>. The published files can be found on our Publications page.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"958\" height=\"604\" src=\"https:\/\/nynkedekkerlab.tudelft.nl\/wp-content\/uploads\/2021\/10\/final_schematic_with_text.png\" alt=\"\" class=\"wp-image-1527\" srcset=\"https:\/\/nynkedekkerlab.tudelft.nl\/wp-content\/uploads\/2021\/10\/final_schematic_with_text.png 958w, https:\/\/nynkedekkerlab.tudelft.nl\/wp-content\/uploads\/2021\/10\/final_schematic_with_text-300x189.png 300w, https:\/\/nynkedekkerlab.tudelft.nl\/wp-content\/uploads\/2021\/10\/final_schematic_with_text-768x484.png 768w\" sizes=\"(max-width: 958px) 100vw, 958px\" \/><figcaption><em>Viral recombination is a major evolutionary mechanism in <em>RNA viruses<\/em> that drives adaptation and<em> genetic diversity. Recombination occurs when at least two virus subspecies co-infect the same (human) host cell and exchange genetic segments. <\/em><br><em>Our study revealed the underlying molecular mechanism and triggers of polymerase switching between different parental virus genomes during RNA replication that can result in recombination and attendant novel genetic combinations.<\/em><\/em><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>We are delighted that our manuscript on copy-back synthesis and recombination in EV-A71 virus is now published in Molecular Cell! Congrats in particular to Richard, Louis, and Bel\u00e9n from our group, as well as to Andrew Woodman of the Craig Cameron group. Thank you to all our other collaborators as well, in particular Shin-Ru Shih, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/posts\/1517"}],"collection":[{"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1517"}],"version-history":[{"count":5,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/posts\/1517\/revisions"}],"predecessor-version":[{"id":1536,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=\/wp\/v2\/posts\/1517\/revisions\/1536"}],"wp:attachment":[{"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nynkedekkerlab.tudelft.nl\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}