Richard Janissen*, Andrew Woodman*, Kuo-Ming Lee, Ibrahim Moustafa, Fiona Fitzgerald, Peng-Nien Huang, Louis Kuijpers, Angela L. Perkins, Daniel A. Harki, Jamie J. Arnold, Belen Solano, Shin-Ru Shih, Craig E. Cameron#, and Nynke H. Dekker#
Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses
(* = equal contribution, # = corresponding author)
submitted (2020); BioRXiv DOI link

S. Deb Roy*, F.M. Asscher*, T. van Laar, and N.H. Dekker
Drug dosage and timing influence the spatial distribution of Polymerase IV
(* = equal contribution)
submitted (2020)

Richard Janissen*, Behrouz Eslami Mossallam*, Irina Artsimovitch#, Martin Depken#, and Nynke H Dekker#
Accounting for RNA polymerase heterogeneity reveals state switching and two long-lived backtrack states that escape through cleavage
(* = equal contribution, # = corresponding author)
submitted (2020); BioRXiv DOI link

Ying Tang*, Seungkyu Ha*, Thomas Begou, Julien Lumeau, H. Paul Urbach, Nynke H. Dekker#, and Aurèle J. L. Adam#
Versatile multilayer metamaterial nanoparticles with tailored optical constants for force and torque transduction
(* = equal contribution, # = corresponding author)
ACS Nano 14, 14895−14906 (2020) PDF SI

A. Kaczmarczyk, M. He, O. Ordu, J. van Noort#, and N.H. Dekker#
Chromatin fibers stabilize nucleosomes under torsional stress
(# = corresponding author)
Nature Communications 11, 126 (2020) PDF SI


Orkide Ordu, Alexandra Lusser, and Nynke H. Dekker
DNA sequence is a major determinant of tetrasome dynamics
Biophysical Journal (2019) PDF SI

Seungkyu Ha, Ying Tang, Maarten van Oene, Richard Janissen, Roland Dries, Belen Solano, Aurele Adam, and Nynke H. Dekker
Single-crystal rutile TiO2 nanocylinders are highly effective transducers of optical force and torque
ACS Photonics, online publication April 22 (2019) PDF SI

Andrew Woodman, Kuo-Ming Lee, Richard Janissen, Yu-Nong Gong, Nynke H. Dekker, Shin-Ru Shih, and Craig Cameron
Predicting Intra- and Intertypic Recombination in Enterovirus 71
Journal of Virology 5, 93 (2019), doi: 10.1128/JVI.02057-18 PDF


R. Janissen*, M. Arens*, N. Vtyurina*, Z. Rivai, N.D. Sunday, B. Eslami-Mossallam, A. Gritsenko, L. Laan, D. de Ridder, I. Artsimovitch, N.H. Dekker#, E. A. Abbondanzieri#, and A. S. Meyer#
Global DNA compaction in stationary-phase bacteria does not affect transcription
(* = equal contribution, # = corresponding author)
Cell 174, 1188-1199 (2018) (online publication July 26) PDF

Kuo-Ming Lee, Yu-Nong Gong, Tzu-Hsuan Hsieh, Andrew Woodman, Nynke H. Dekker, Craig Cameron, and Shin-Ru Shih
Discovery of Enterovirus A71-like non-structural genome in recent circulating viruses of the Enterovirus A species
Emerging Microbes & Infections 7, 111 (2018) (online publication June 21) PDF

Artur Kaczmarczyk, Thomas B. Brouwer, Chi Pham, Nynke H. Dekker, and John van Noort
Methods for probing chromatin structure with magnetic tweezers
Nanoscale Imaging: Methods and Protocols, Methods in Molecular Biology 1814, 297-323 (2018) PDF

M. M. van Oene*, S. Ha*, T. Jager, M. Lee, F. Pedaci, J. Lipfert, and N. H. Dekker
Quantifying the Resolution of Single-Molecule Torque and Twist Measurements Using Allan Variance
(* = equal contribution)
Biophysical Journal 114, 1970–1979 (2018) (online publication April 24) PDF Extended PDF

O. Ordu, L. Kremser, A. Lusser, and N.H. Dekker
Modification of the Histone Tetramer at the H3-H3 Interface Impacts Tetrasome Conformations and Dynamics
Journal of Chemical Physics 148, 123323 (2018) PDF


Bojk A. Berghuis, Vlad-Stefan Raducanu, Mohamed M. Elshenawy, Slobodan Jergic, Martin Depken, Nicholas E. Dixon, Samir M. Hamdan, and Nynke H. Dekker
What is all this fuss about Tus? Comparison of recent findings from biophysical and biochemical experiments
Critical Reviews in Biochemistry and Molecular Biology 53(1):49-63 (2017) (published online November 7) PDF SI

David Dulin, Jamie J. Arnold, Theo van Laar, Hyung-Suk Oh, Cheri Lee, Daniel A. Harki, Martin Depken, Craig E. Cameron, and Nynke H. Dekker
Signatures of nucleotide analogue incorporation by an RNA-dependent RNA polymerase revealed by using high-throughput magnetic tweezers
Cell Reports 21, 1063–1076 (2017) PDF Extended PDF

Artur Kaczmarczyk, Abdollah Allahverdi, Thomas Brouwer, Lars Nordenskiöld, Nynke H. Dekker, and John van Noort
Single-molecule force spectroscopy on H4 tail cross-linked chromatin reveals fiber folding
Journal of Biological Chemistry 292(42), 17506–17513 (2017) PDF

Roy de Leeuw, Peter Brazda, M. Charl Moolman, Belen Solano, and Nynke H. Dekker
Measuring in vivo protein dynamics throughout the cell cycle using microfluidics
Methods in Molecular Biology, online publication August 28 (2017) PDF

Franziska Kriegel, Niklas Ermann, Ruaridh Forbes, David Dulin, Nynke H. Dekker, and Jan Lipfert
Probing the Salt Dependence of the Torsional Stiffness of DNA by Multiplexed Magnetic Torque Tweezers
Nucleic Acids Research 45, 5920-5929 (2017) (online publication April 29) PDF SI

Maarten M. van Oene, Laura E. Dickinson, Bronwen Cross, Francesco Pedaci, Jan Lipfert, and Nynke H. Dekker
Applying torque to the Escherichia coli flagellar motor using magnetic tweezers
Scientific Reports 7, 43285 (2017) PDF


O. Ordu, A. Lusser, and N.H. Dekker
Recent insights from single-molecule studies into nucleosome structure and dynamics
Biophysical Reviews 8, 33-49 (2016) (online publication October 16) PDF

D. Dulin, Z. Yu, T. Cui, B.A. Berghuis, S.M. Depken, and N.H. Dekker,
Real-time observation of replicative helicase assembly onto single-stranded DNA
BioRxiv, doi: (2016)

M.C. Moolman*, S. Tiruvadi Krishnan*, J.W.J. Kerssemakers, R. de Leeuw, V. Lorent, D.J. Sherratt, and N.H. Dekker
The progression of replication forks at natural replication barriers in live bacteria
Nucleic Acids Research 44 (13), 6262-6273 (2016) (online publication May 10) PDF SI
(* = equal contribution)

Natalia N. Vtyurina, David Dulin, Margreet W. Docter, Anne S. Meyer, Nynke H. Dekker, and Elio A. Abbondanzieri
An Ising model describes hysteresis in the process of DNA compaction by Dps
Proceedings of the National Academy of Sciences (USA) 113 (18), 4982–4987 (2016) PDF

S. Ha, R. Janissen, Ye.Ye. Ussembayev, M.M. van Oene, B. Solano, and N.H. Dekker
Tunable Top-Down Fabrication and Functional Surface Coating of Single-Crystal Titanium Dioxide Nanostructures and Nanoparticles
Nanoscale 8, 10739-10748 (2016) (online publication April 18) PDF

B.A. Berghuis, M. Koeber, T. van Laar, and N.H. Dekker
High-throughput, high-force probing of DNA-protein interactions with magnetic tweezers
Methods 105, 90-98 (2016) (online publication March 30) PDF